MAP Kinase Signaling System

《英文msh詞典》MAP Kinase Signaling System
[主題詞] MAP Kinase Signaling System
[同義詞] MAP Kinase Cascade
[同義詞] MAP Kinase Signaling Pathways
[入口詞] MAP Kinase Modules
[入口詞] MAP Kinase Signaling Cascades
[入口詞] Cascade,MAP Kinase
[入口詞] Cascades,MAP Kinase
[入口詞] Kinase Cascade,MAP
[入口詞] Kinase Cascades,MAP
[入口詞] Kinase Module,MAP
[入口詞] Kinase Modules,MAP
[入口詞] MAP Kinase Cascades
[入口詞] MAP Kinase Module
[入口詞] Module,MAP Kinase
[入口詞] Modules,MAP Kinase
[中文釋義] MAP激酶信號系統
[英文釋義] An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators,which act in response to extracellular stimuli,trigger the cascades by activating the first member of a cascade,MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals,there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway,the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway,and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.